glutathione what is and why must we protect patient access to it? What is Glutathione? What Are

Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected

This review highlights oxidative stress as a major contributor to brain aging and neurological disease, with the brain particularly vulnerable due to its high metabolic activity

Nature 509(7501):439-446

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